Interfacial polymerisation was mainly developed toward the end of the 1960s, leading to applications in microcapsule production by the mid-1970s. The process consists in the dispersion of one phase containing a reactive monomer, into a second immiscible phase to which is added a second monomer. Both monomers react at the droplet surface (interface), forming a polymeric membrane. Over the last 50 years, many studies have been reported, but very few have provided a comprehensive review of this technology. This contribution reviews microcapsule production by interfacial polymerisation from the chemical, physico-chemical and physical perspectives, providing a tool for understanding and mastering this production technology, but also providing guidance toward improvements for future process design.