The elimination mefenamic acid (MA) as a pollutant from the aquatic environment using Hg lamp during a catalytic photodegradation process using supported ZnO-CuO onto clinoptilolite nanoparticles (NCP) was the aim of the study. Raw and supported clinoptilolite were characterized by FF-IR, XRD, DRS, TEM and SEM techniques. The changes of MA concentration determined by UV-vis double beam spectrophotometer at lambda(max) 285 nm and used for the calculation of its degradation extent. Better degradation efficiencies obtained for the supported the hybridized ZnO-CuO system onto NCP with respect to unsupported one and supported/unsupported ZnO and CuO. The degradation efficiencies are dependent to the experimental conditions and hence the parameters were optimized to reach the highest efficiencies. (C) 2015 Elsevier B.V. All rights reserved.