Soluble oligomeric styrene supports are reported here with high loading capacities of 1.5-1.6 mmol/g similar to resins used in solid phase peptide synthesis. Oligoether and alkyl chains are incorporated into the scaffold to improve the support solubility and act as spacers between the attachment sites. Amino acids have been attached to the support in 59-85% yields and 0.87-1.3 mmol/g loading. The supports have been used to synthesize tri- to hexapeptides in 38-64% yields using only 2 equivalents of coupling reagents, which is much lower than the amount of reagents typically used in solid phase synthesis. A modular synthetic approach is used to obtain the supports so that any efficient styrene-based attachment site can be readily incorporated into our soluble support scaffold. (C) 2015 Wiley Periodicals, Inc.