In this study, supercritical carbon dioxide extraction (SC-CO2) was studied as a method to recover oil from salmon waste. Experiments at pressures of 15, 25, and 35 MPa, temperatures of 313, 333, and 353 K, and CO2 flow rates of 0.18-0.48 kg/h were conducted and the yield compared. The yields at 35 MPa, temperatures of 313, 333, and 353 K, and CO2 flow rates of 0.18 kg/h were approximately 39, 46, and 41 (wt.%). A process model based on intra-particle diffusion (D-e) and external mass transfer of fish oil (k(f)) is presented for the supercritical extraction process. The adsorption equilibrium constant (K) is determined by fitting the theoretical extraction curve to the experimental data. The model using the best fit of theoretical extraction curve correlated the experimental data satisfactorily with AAD (%) ranged from 2.4 to 10.6%. (C) 2015 Elsevier B.V. All rights reserved.