In this study, sub and supercritical CO2 are used as effective solvents to impregnate hydrogen peroxide (H2O2) into cellulose acetate (CA) non-woven mats. As much as 25 wt% H2O2 can be impregnated at operating conditions of 25-45 degrees C and 1200 psig. Thermal gravimetric analysis shows that H2O2-loaded CA mats lose more than 60% of available H2O2 when quickly heated to 37 degrees C and held at this temperature for 60 min. However, in comparison, pure H2O2-H2O (50:50 w/w) solution evaporates 100% within 15 min at this same temperature. Shelf-life studies show that H2O2-loaded CA mats lose similar to 50% and similar to 100% of available H2O2 in 30 days, when stored at 2-8 degrees C and 20-23 degrees C, respectively. H2O2 slowly diffuses and subsequently evaporates from the CA mat at a rate determined by the diffusion of H2O2 through the CA fibers. We envision applying a thin polymer coating to the CA mat to suppress diffusional losses of H2O2, thus leading to an increased product shelf-life. These mats should find use as bandages for the continuous delivery of O-2 for advanced wound care. In vitro studies presented here demonstrate that the developed bandages produce O-2 at a controlled rate for 24 h. (C) 2015 Elsevier B.V. All rights reserved.