Journal of the American Chemical Society, Vol.137, No.27, 8708-8711, 2015
Palladium-Catalyzed Intramolecular Insertion of Alkenes into the Carbon Nitrogen Bond of beta-Lactams
The carbon-nitrogen bond of beta-lactams is cleaved by palladium(0), and an alkene is intramolecularly inserted therein. The following reductive elimination produces nitrogen-containing benzo-fused tricycles in good to high yields.