During the well drilling process, particles are produced in different shapes. The shape of particles can influence the characteristics of particles transport process. The aim of this work is to analyze the effects of particle shape on the transportation mechanism. For this purpose, a three-dimensional model is prepared for simulation of particle transportation with spherical and non-spherical shapes, during deviated well drilling. The motion of particles and the non-Newtonian fluid flow are simulated via discrete element method and CFD, respectively. The two-way coupling scheme is used to incorporate the effects of fluid-particle interactions. Three different samples of non-spherical shapes are constructed using multi-sphere method. The interactions of particle-particle/wall/drill pipe are taken into account via Hertz-Mindlin model. Simulations are carried out for some laboratory-scale configurations and fair agreements with the experimental data available in the literature are established.