Applied Chemistry, Vol.4, No.1, 304-307, May, 2000
발암물질인 아플라톡신 G1 에폭시드의 가메탄올 분해에 관한 연구
The Studies on the Methanolysis of Aflatoxin G1 Epoxide in Cancer Compound
The methanolysis of anhydrous methyl alcohol (MeOH) with Aflatoxin G1 (AFG1) exo-9,10-epoxide formed predominantly a trans methoxy alcohol (95% over), but the methanolysis of MeOH under acidic conditions with AFG1 exo-9,10-epoxide formed a trans methoxy alcohol (84%) and a cis methoxy alcohol(16%). And, the methanolysis of anhydrous MeOH with AFG1 endo-9,10-epoxide formed a trans methoxy alcohol (80%) but the methanolysis of MeOH under acidic conditions with AFG1 endo-9,10-epoxide formed a cis methoxy alcohol(20%). The methanolysis studies reveal exclusive trans opening of exo-epoxide and under acid conditions, the endo-epoxide formed mixtures of trans and cis(4:1) ratio products.