Selected natural extracts formulated as nanostructured glycerol - water mixtures have been in vitro tested in order to establish the optimum balance among cosmetic efficacy/human health and ecosafety. In our work, cytotoxicity and antioxidant activity have been studied on the natural extracts of bilberry, red rose, raspberry, hazelnut, wild strawberry, marigold and blackberry. Cytotoxicity effects have been estimated on the cell culture system from human fibroblast. The antioxidant activity has been estimated by chemiluminescence technique (CL) and by chemical determination of flavones and the tannin contents. In order to obtain cosmetic formulations, we selected bilberry, blackberry, red rose and raspberry extracts. These data have been completed by determination of stability in thermo and photooxidative conditions (irradiation UV at 290-400 nm domain). The behavior of extracts in these conditions justified their utilization in cosmeceuticals with photoprotective properties.