This study describes the novel synthesis of a homologous series of quinoline-containing liquid crystalline 2-(4-alkylphenyl)-6-methoxyquinolines (nPQOMe, n=4-8) compounds. Preparation of these compounds was completed in the overall two-step reaction and fair to good yields (47-60%) were obtained. Thermotropic behaviors of these liquid crystalline compounds were investigated using differential scanning calorimetry and polarized optical microscopy. Liquid crystals of these 2-(4-alkylphenyl)-6-methoxyquinolines display only nematic phase.