화학공학소재연구정보센터
Molecular Crystals and Liquid Crystals, Vol.523, 273-281, 2010
Therapeutic Effect of Flavonoids Derived from Plantago Species
Flavonoids are widely distributed in plants fulfilling many functions including producing yellow or red/blue pigmentation in flowers and protection from attack by microbes and insects. Current research shows for these compounds an anti-allergic, and an anti-cancer activity. The objectives of the research are the investigation of other therapeutic effects of flavonoid fraction separated from alcoholic extract of Plantago sp., as following: sedative, analgesic and anti-microbial activities. The physical-chemical properties of the extract were also investigated. The results obtained indicate the presence of D-apigenin, lutelin, scutellarin, baicalein, nepetin, hispidulin, plantagoside, potassium and microelements in the flavonoids extract. The anti-inflammatory effect (study performed on mice with pletismometric method)) was meaningful after 120 minute at a dose of 400mg/kg body. The sedative effect (study performed on mice using the writhing test) was meaningful after 30 minutes at 400mg/kg body. The antimicrobial activities (study performed oin vitroo using Kirby Bauer method) reveal the intense bacteriostatic activity against the microorganisms like Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus sp. This research suggests that plantain may be effective in the treatment of inflammatory and microbial disease but further studies are needed.