Two kinds of organic layers deposited on a silicon patterned substrate from a solution at room temperature have been investigated by scanning electron and optical microscopies, by studying the photoresponse, and by measuring the I-V characteristics. The organic pharmaceutical materials used are the following: thiamine diphosphate (vitamin B-1) and metamizole sodium (MS) (analgine). Both hybrids possess the photovoltaic (PV) properties. Investigations of the PV performance versus the solar energy power have indicated that the best samples of a MS-nSi hybrid had efficiency EFF=1.97% for the irradiation power E=11.6mW/cm(2) and EFF=1.43% for E=63.8mW/cm(2).