New synthetic approaches for the preparation of various anisotropic and liquid-crystalline compounds with different combinations of cyclic, bridge, terminal fragments and lateral substituents are proposed and realized. Both chiral and nonchiral nematic, smectic mesomorphic and anisotropic compounds were prepared by the transformations of the corresponding 3,6-disubstituted cyclohex-2-enones, 2,5-disubstituted cyclohexanones, 5-substituted cyclohexan-1,3-diones, 1,2-disubstitiuted cyclopropanoles and 3,5-disubstitiuted 2-isoxazolines, substituted cyclohex-2-enonyl-2-isoxazolines.