4-Tosyloxychalcone derivative, C23H20O4S, was synthesized and characterized by infrared and H-1 NMR spectral studies. Grown crystal was further characterized by single crystal X-ray diffraction studies. The compound crystallizes in monoclinic space group C2/c with unit cell parameters a = 33.431 (6) angstrom, b = 5.8451 (10) angstrom, c = 21.439 (4) angstrom, Z = 8, and V = 3848.2 (12) angstrom(3). The crystal packing is mainly stabilized by CH center dot center dot center dot pi interaction. There are no significant intermolecular interactions beyond van der Waals forces observed in the solid state structure of the compound.