A set of 14 mono-organotin(IV) derivatives of general formulae n-BuSnCIL2 and n-BusnL(3), where 'L' are various non-steroidal anti-inflammatory drugs (NSAIDs), were synthesized and structurally characterized by vibrational, H-1, C-13 and Sn-119 spectroscopies and mass spectrometry to propose their structure. Biological activity data (antibacterial, antifungal and cytotoxicity) of the synthesized complexes were compared with the precursors to establish the significance of the complexes.