화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Applied Chemistry for Engineering, Vol.27, No.2, 115-122, April, 2016
DOI10.14478/ace.2016.1029  Export Citation
자연계에 존재하는 다기능성 소재 : 멜라닌
Melanin: A Naturally Existing Multifunctional Material
엄태식, 우경배, 심봉섭†
  • 인하대학교 화학공학과
Taesik Eom, Kyungbae Woo, and Bong Sup Shim†
  • Department of Chemical Engineering, Inha University, 100 Inharo, Nam-gu, Incheon 22212, South Korea
E-mail:
초록
사람의 머리카락, 눈, 피부 등에서 발견되는 멜라닌은 자연의 생물체에 존재하는 어두운 색소를 가르치는 통칭이다. 멜라닌은 자유 라디컬을 흡수해서 제거하는 특성을 가지고 있어, 해로운 UV 광선이 생체로 침투할 때, 세포 및 조직을 보호하는 역할을 한다. 또한, 전기적 전도성 및 이온 전도성을 가지고 있으며, 항산화성, 젖은 상태에서의 접착성, 금속이온 킬레이팅 등 다기능성으로 인해, 다양한 분야에서의 응용이 주목받고 있다. 자연계에 존재하는 생체 멜라닌의 구조를 정확하게 정의할 수는 없지만, 멜라닌의 응용 분야는 센서, 의료기기 등으로 확대되고 있다. 본 미니총설에서는 멜라닌의 원천과 합성, 구조와 특성, 그리고 다양한 분야로의 응용 가능성에 대해서 구체적으로 논의한다.
Melanin is a common name used for a certain type of natural dark pigments existing in living organisms, particularly in human hair, eyes, and skin. The unique free radical scavenging effect of melanine could help protecting cells and tissues from harmful UV light. While their exact molecular structures in nature are not still well defined, their multifunctional properties including electrical and ionic conductivities, antioxidation, wet adhesion, and metal ion chelation, are highlighted for the potential applications in bioorganic electronics including biomedical sensors and devices. In this mini-review, we will discuss sources, synthesis methods, structures and multifunctional properties of melanin materials in addition to current research directions on a wide range of applications.
Keywords:melanin;eumelanin;polydopamine;natural pigments;biocompatible;bioorganic electronics
  1. Riley PA, Melanin, Int. J. Biochem. Cell Biol., 29(11), 1235 (1997)
  2. d’Ischia M, Wakamatsu K, Napolitano A, Briganti S, Garcia-Borron JC, Kovacs D, Meredith P, Pezzella A, Picardo M, Sarna T, Simon JD, Ito S, Pigment Cell Melanoma Res., 26(5), 616 (2013)
  3. Solano F, New J. Sci., 2014, 1 (2014)
  4. Grishchuk VP, Davidenko SA, Zholner ID, Verbitskii AB, Kurik MV, Piryatinskii YP, Tech. Phys. Lett., 28(11), 896 (2002)
  5. Capozzi V, Perna G, Carmone P, Gallone A, Lastella M, Mezzenga E, Quartucci G, Ambrico M, Augelli V, Biagi PF, Ligonzo T, Minafra A, Schiavulli L, Pallara M, Cicero R, Thin Solid Films, 511, 362 (2006)
  6. Powell MR, Rosenberg B, Biopolymers, 9(11), 1403 (1970)
  7. McGinness JE, Science, 177(4052), 896 (1972)
  8. McGinness J, Corry P, Proctor P, Science, 183(4127), 853 (1974)
  9. Capelletti PB, Crippa PR, Romeo N, ECS J. Solid State Sci. Technol., 126(7), 1207 (1979)
  10. Osak W, Tkacz K, Czternastek H, Slawinski J, Biopolymers, 28(11), 1885 (1989)
  11. Ligonzo T, Ambrico M, Augelli V, Perna G, Schiavulli L, Tamma MA, Biagi PF, Minafra A, Capozzi V, J. Non-Cryst. Solids, 355(22-23), 1221 (2009)
  12. Bettinger CJ, Bruggeman PP, Misra A, Borenstein JT, Langer R, Biomaterials, 30(17), 3050 (2009)
  13. Rozanowska M, Sarna T, Land EJ, Truscott TG, Free Radic. Biol. Med., 26(5-6), 518 (1999)
  14. Felix CC, Hyde JS, Sarna T, Sealy RC, J. Am. Chem. Soc., 100(12), 3922 (1978)
  15. d’Ischia M, Napolitano A, Pezzella A, Meredith P, Sarna T, Angew. Chem.-Int. Edit., 48(22), 3914 (2009)
  16. Liu Y, Simon JD, Pigment Cell Res., 16(1), 72 (2003)
  17. d’Ischia M, Napolitano A, Ball V, Chen CT, Buehler MJ, Acc. Chem. Res., 47(12), 3541 (2014)
  18. Bothma JP, de Boor J, Divakar U, Schwenn PE, Meredith P, Adv. Mater., 20(18), 3539 (2008)
  19. da Silva MIN, Deziderio SN, Gonzalez JC, Graeff CFO, Cotta MA, J. Appl. Phys., 96(10), 5803 (2004)
  20. Liu YL, Ai KL, Lu LH, Chem. Rev., 114(9), 5057 (2014)
  21. Kim IG, Nam HJ, Ahn HJ, Jung DY, Electrochim. Acta, 56(7), 2954 (2011)
  22. Kang K, Lee S, Kim R, Choi IS, Nam Y, Angew. Chem.-Int. Edit., 51(52), 13101 (2012)
  23. Kim YJ, Wu W, Chun SE, Whitacre JF, Bettinger CJ, Proc. Natl. Acad. Sci. USA, 110(52), 20912 (2013)
  24. Wolbarsht ML, Walsh AW, George G, Appl. Opt., 20(13), 2184 (1981)
  25. Rosei MA, Mosca L, Galluzzi F, Synth. Met., 76(1-3), 331 (1996)
  26. Mostert AB, Powell BJ, Pratt FL, Hanson GR, Sarna T, Gentle IR, Meredith P, Proc. Natl. Acad. Sci. USA, 109(23), 8943 (2012)
  27. Chen CT, Ball V, de Almeida Gracio JJ, Singh MK, Toniazzo V, Ruch D, Buehler MJ, ACS Nano, 7(2), 1524 (2013)
  28. Wuensche J, Cicoira F, Graeff CFO, Santato C, J. Mater. Chem. B, 1(31), 3836 (2013)
  29. Kai D, Prabhakaran MP, Jin G, Ramakrishna S, J. Mater. Chem. B, 1(17), 2305 (2013)
  30. Gargiulo V, Alfe M, Capua RD, Togna AR, Cammisotto V, Fiorito S, Musto A, Navarra A, Parisi S, Pezzella A, J. Mater. Chem. B, 3(25), 5070 (2015)
  31. Borovansky J, Elleder M, Pigment Cell Res., 16(3), 280 (2003)
  32. Kim DJ, Ju KY, Lee JK, Bull. Korean Chem. Soc., 33(11), 3788 (2012)
  33. Wang D, Chen C, Ke X, Kang N, Shen Y, Liu Y, Zhou X, Wang H, Chen C, Ren L, ACS Appl. Mater. Interfaces, 7(5), 3030 (2015)
  34. Shanmuganathan K, Cho JH, Iyer P, Baranowitz S, Ellison CJ, Macromolecules, 44(24), 9499 (2011)
  35. Araujo M, Viveiros R, Correia TR, Correia IJ, Bonifacio VDB, Casimiro T, Aguiar-Ricardo A, Int. J. Pharm., 469(1), 140 (2014)
  36. da Silva MP, Fernandes JC, de Figueiredo NB, Congiu M, Mulato M, de Oliveira Graeff CF, AIP Adv., 4(3), 037120 (2014)
  37. Bernsmann F, Frisch B, Ringwald C, Ball V, J. Colloid Interface Sci., 344(1), 54 (2010)
  38. Wu TF, Hong JD, Sens. Actuators B-Chem., 224, 178 (2016)
  39. Rubianes MD, Arribas AS, Bermejo E, Chicharro M, Zapardiel A, Rivas G, Sens. Actuators B-Chem., 144(1), 274 (2010)
  40. Kim YJ, Wu W, Chun SE, Whitacre JF, Bettinger CJ, Adv. Mater., 26(38), 6572 (2014)
  41. Dong W, Wang Y, Huang C, Xiang S, Ma P, Ni Z, Chen M, J. Therm. Anal. Calorim., 115(2), 1661 (2014)
  42. Xiao M, Li Y, Allen MC, Deheyn DD, Yue X, Zhao J, Gianneschi NC, Shawkey MD, Dhinojwala A, ACS Nano, 9(5), 5454 (2015)
  43. Wu TF, Hong JD, Biomacromolecules, 16(2), 660 (2015)