Despite extraordinary developments in the research of 2D inorganic nano-materials, a scalable and generalized synthetic method toward 2D oxide materials that lack layered lattice structures is still challenging. Herein, an easy and versatile solution-based route to synthesize oxides with layered nanostructures by combining sol-gel method with graphene oxide (GO) paper templates is reported. GO can stack together to form a paper-like membrane, the gap between two GO layers provides ideal 2D space to template the growth of oxide nanolayers. By this simple strategy, the gaps are filled successfully with polycrystalline TiO2, ZnO, Fe2O3, and amorphous SiO2 nanolayers with thickness of 1-5 nm. Single or multilayers of the oxide-based ceramic/glass nanolayers for applications in electronics, catalysts, energy storage, and gas separation can be expected; as an example, it is shown that layered Fe2O3 electrodes exhibit high performance for lithium-ion battery due to enhanced electrical connections between the 2D nanolayers.