Chemistry Letters, Vol.45, No.3, 353-355, 2016
Chiral Ammonium Hypoiodite Salt-catalyzed Enantioselective Oxidative Cycloetherification to 2-Acyl Tetrahydrofurans
2-Acyl tetrahydrofuran is a fundamental structure in natural products and pharmaceuticals. We achieved chiral quaternary ammonium hypoiodite salt-catalyzed enantioselective oxidative cycloetherification of delta-hydroxyketone derivatives. The corresponding 2-acyl tetrahydrofurans were obtained in high chemical yield with high enantioselectivity.