Composite to metal adhesively bonded joints generates critical points where geometry and material properties change abruptly. These points (multimaterial corners) are potential locations for failure initiation. There exist proposals predicting the initiation of failure at these multimaterial corners using a Fracture Mechanics approach, in which the Generalized Stress Intensity Factors (GSIFs) at the multimaterial corner control the failure initiation. The calculation of these GSIFs at anisotropic multimaterial corners involves not-straightforward calculations of the stress singularities and characteristic angular functions, numerical modeling of the joint and a careful postprocessing of the results. In this study a parametric Finite Element Analysis has been carried out allowing the generation of plots to calculate the GSIFs for unit values of the axial force, shear force and bending moment at one end of the overlap length. These results allow calculating the GSIFs at the multimaterial corners by a simple beam analysis of the joint, the use of these plots and the application of the superposition principle, for their use in the prediction of failure initiation by means of the singular parameters of the joint. Additionally, experiments have been carried out to propose an explicit failure criterion based on GSIF and Generalized Fracture Toughness values which fit very well with double-lap joint test results.