Innovative and efficient ways to carry out numerical simulations are worth of investigation to reduce the computational complexity of building models and make it possible to solve complex problems. This paper presents a reduced order model, based on Proper Generalised Decomposition (PGD), to assess 2-dimensional heat and moisture transfer in walls. This model is associated with the multizone model Domus using an indirect coupling method. Both models are co-simulated to perform whole-building hygrothermal simulation, considering 2D transfer in walls. The whole-building model is first validated with data from the IEA Annex 41. Then, a case study is considered taking into account a 2-zones building with an intermediary shared wall modelled in 2 dimensions to illustrate the importance of the technique to analyse the hygrothermal behaviour of the wall. It has been highlighted that the whole model enables to perform more precisely analyses such as mould growth on the internal surface. In addition, important theoretical numerical savings (90%) are observed when compared to the large original model. However, the effective numerical savings are not so important (40%) due to the limitations of the co-simulation method. (C) 2015 Published by Elsevier B.V.