A gravimetric method was used to determine the solubility of maltitol in five pure solvents, methanol water mixtures, and ethanol water mixtures at different temperatures from 298.15 to 323.15 K. At a given temperature, the solubility of maltitol in the five pure solvents follows this order: 2-propanol < ethanol < methanol < DMF < water. Compared with the modified Van't Hoff equation, the modified Apelblat equation presents a better consistence with the solubility of maltitol in different pure solvents. The solubility of maltitol increases with rising temperature, but decreases with the increase of the initial mole fraction of methanol or ethanol. It is found that the modified Apelblat equation can give better correlation results in methanol water mixtures and ethanol water mixtures than the combined nearly ideal binary solvent/Redlich Kister equation or the two kinds of Jouyban-Acree models.