The cleanability of food contact surfaces is determined by surface characteristics and the properties of the soiling material. Effects of selected physicochemical parameters of biopolymer soils on the removal from stainless steel were studied using a laboratory flow cell system with continuous removal measurement and, additionally, gravimetric detection. The results show the potential for improving cleaning processes on the basis of structural properties of the biopolymers. A higher cleaning efficiency was achieved when surface energy and cationic charge of the polymers was lower, indicating that adhesive interactions (van der Waals forces of attraction and electrostatic forces) between surface and polymer play a dominant role. The effects of pre-heating treatments of the soils, inducing molecular changes, on removal behavior were however not significant. The results indicate that a holistic view of product and process design is useful to develop efficient cleaning protocols. (C) 2016 Published by Elsevier Ltd.