Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo

Gijin Jeong; Jee-Wook Lee; Gyeonghyeon Gong; Hyeji Ko; Ikjang Choi; Hyeonglim Seo; Youngbok Lee; Niki M. Zacharias Millward; Pratip K. Bhattacharya

Journal of Industrial and Engineering Chemistry, Vol.36, 224-228, April, 2016

DOI10.1016/j.jiec.2016.02.002 Export Citation

Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo

Gijin Jeong, Jee-Wook Lee¹, Gyeonghyeon Gong, Hyeji Ko, Ikjang Choi, Hyeonglim Seo, Youngbok Lee^†, Niki M. Zacharias Millward^{2, †}, and Pratip K. Bhattacharya^{2, †}

Department of Applied Chemistry, Hanyang University, Ansan 15588, South Korea
¹School of Advanced Materials Engineering, Kookmin University, Seoul 02707, South Korea
²Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States, USA

E-mail:, ,

We utilized dynamic nuclear polarization to hyperpolarize three metabolic imaging agents as single agents and together (co-polarization with two different organic radicals; OX63 and BDPA). In addition, we describe our initial two slice selective spectroscopy in vivo experiments in mice. These techniques along with advances by other laboratories will allow for multiple metabolic pathways to be imaged in real-time and in vivo.

Keywords:Hyperpolarization;Dynamic nuclear polarization;MR spectroscopy and imaging;In vivo metabolic MR

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[1] Warburg O, Science, 123, 309 (1956)

[2] Kurhanewicz J, Swanson MG, Nelson SJ, Vigneron DB, J. Magn. Reson. Imaging, 16, 451 (2002)

[3] Spratlin JL, Serkova NJ, Eckhardt SG, Clin. Cancer Res., 15, 431 (2009)

[4] Abragam A, Goldman M, Rep. Prog. Phys., 41, 395 (1978)

[5] Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K, Proc. Natl. Acad. Sci. U. S. A., 100, 10158 (2003)

[6] Lee Y, Appl. Spectrosc. Rev., 51, 190 (2016)

[7] Golman K, in’t Zandt R, Lerche M, Pehrson R, Ardenkjaer-Larsen JH, Cancer Res., 66, 10855 (2006)

[8] Keshari KR, Wilson DM, Chem. Soc. Rev., 43, 1627 (2014)

[9] Golman K, Ardenaer-Larsen JH, Petersson JS, Mansson S, Leunbach I, Proc. Natl. Acad. Sci. U. S. A., 100, 10435 (2003)

[10] Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM, Nat. Med., 13, 1382 (2007)

[11] Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA, Sci. Transl. Med., 5, 198ra1 (2013)

[12] Wilson DM, Kurhanewicz J, J. Nucl. Med., 55, 1567 (2014)

[13] Lee Y, Zacharias NM, Piwnica-Worms D, Bhattacharya PK, Chem. Commun., 50, 13030 (2014)

[14] Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjaer-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM, Nature, 453, 940 (2008)

[15] Zacharias NM, Chan HR, Sailasuta N, Ross BD, Bhattacharya P, J. Am. Chem. Soc., 134, 934 (2011)

[16] Lumata L, Merritt ME, Malloy CR, Sherry AD, Kovacs Z, J. Phys. Chem. A, 116, 5129 (2012)