Five novel chiral camphor Schiff bases have been synthesized and utilized as ligands in asymmetric Henry reaction between nitromethane and aldehydes. The diastereoisomeric Schiff bases 5a and 5a' were separated successfully and gave completely different absolute configurations in the reaction. The reactions were carried out with CuCl-Schiff base 5a complex under mild condition with good yields and enantioselectivities. This is the first time that camphor-derivated Schiff bases were used as ligands in asymmetric Henry reaction. (C) 2016 Elsevier B.V. All rights reserved.