A novel chemically modified electrode is constructed based on a multiwalled carbon nanotubes, nickel(l) hydroxide nanoparticles and MCM-41 molecular sieve composite modified glassy carbon electrode. It is demonstrated that the sensor can be used for the simultaneous determination of dopamine (DA), acetaminophen (ACT) and indomethacin (INDO). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA). Under the optimum conditions the modified electrode provides a linear response versus DA concentrations in the range of 1.5-45 mu M and 70-35 mu M, ACT concentrations in the range of 0.2-20 mu M and 20-220 mu M and INDO concentrations in the range of 0.8-40 mu M and 60-160 mu M, respectively using the differential pulse voltammetry method. The modified electrode was used for determination of DA, ACT and INDO in real samples with satisfactory results. (C) 2015 Elsevier B.V. All rights reserved.