In the present work, the PtPdPt nanocomposites with an average diameter of 22.3 nm are successfully anchored onto graphene nano-sheets by using a facile electrodeposition process, as advanced direct methanol fuel cell (DMFC) electrocatalysts. The resulting PtPdPt/graphene nanocomposites are developed toward highly active catalysts for methanol oxidation. Experimental results reveal that the PtPdPt/graphene catalysts exhibit significantly enhanced electrocatalytic performance (j(p) = 25.63 mA cm(-2)) and higher tolerance to carbon monoxide poisoning (I-F/I-B = 1.602) generates in the process of methanol oxidation when compared with traditional Pt/graphene (j(p) = 7.20 mA cm(-2); I-F/I-B = 1.178) and PtPd/graphene catalysts (j(p) = 12.86 mA cm(-2); I-F/I-B = 1.442). This study implies that the prepared catalysts have great potential applications in direct methanol fuel cells. (C) 2015 Elsevier B.V. All rights reserved.