In the present work, magnesium oxide nanoflakes (MgONF) were synthesized using cetyl trimethyl ammonium bromide (CTAB) in a co-precipitation method. The prepared MgONF were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). They were used for the preparation of modified carbon-paste electrode and successfully used to study the electrochemical behavior of ezetimibe (Eze) in phosphate buffer solution (PB, pH 7.0) by cyclic voltammetric technique (CV). The results show that MgONF-modified CPE can remarkably enhance the electrocatalytic activity towards the oxidation of Eze. The effect of pH and scan rate was also investigated. A linear relationship was obtained between the anodic peak current and the Eze concentration in the range 2 x 10(-7) to 1.0 x 10(-5) M with a correlation co-efficient of 0.999. The detection limit (LOD) and quantification limit (LOQ) at MgONF-modified CPE were found to be 5 x 10(-8) and 2 x 10(-7) M respectively by differential pulse voltammetric technique (DPV). The proposed method was successfully applied for the determination of Eze in commercial tablet sample. (C) 2016 Elsevier B.V. All rights reserved.