A study of single proteins, beta-lactoglobulin and lysozyme of different sizes and electrical characteristic as a function of pH, ionic strength and nature of salt (NaCl or CaCl2) allows to evaluate the filtration performances. Streaming potential measurements confirm that proteins contribute to the net charge of the system and that the protein tranfer through mineral membranes is governed by ionic and steric exclusion phenomena. This work shows the correlation between protein transmission and streaming potential values which takes into account steric and ionic exclusion. The ionic repulsion decreases the transmission. This one depends on membrane net charge characterised by streaming potential, which depends on the solution composition. This model, which does not take into account interactions between protein and membrane fouling leads to an overestimation of calculated transmission values when proteins are in a mixture. However, it allows a correct estimation of transmission variations versus the studied variables: pH and ionic strength.