Fluidized bed reactors (FBRs) have been developed to establish multiple temperature zones for various industrial processes. To overcome the common weakness, this work proposed to spray liquid into bottom and upper zones, respectively, to realize multiple temperature zones FBR (MTZFBR). Temperature, pressure, and acoustic emission techniques were applied to fully characterize liquid interaction and hydrodynamics. Compared with the bottom liquid-spraying approach, the upper liquid-spraying approach showed higher temperature difference (DT) and better fluidization stability, thus was selected for further control studies. Effects of liquid flow rate, static bed height, and inlet gas temperature on MTZFBR were studied systematically. The results showed that increasing liquid evaporation behavior or decreasing liquid bridge behavior enhance DT and fluidization stability and vice versa. G-L-S fluidization pattern depended mostly on the liquid behaviors and fluidization stability, and thus the stabilized MTZFBR could be regarded as a coexisted mode of two distinctive G-L-S fluidization patterns. (C) 2016 American Institute of Chemical Engineers