A dehydration of fructose in the water/methyl isobuthyl ketone (MIBK) biphasic system can yield 5hydroxymethylfulfural (IIMF) to be successfully extracted into the organic MIBK phase. The [IMF production and yield in MIRK phase was discussed by using a simplified model taking into consideration of the slug flow. The extraction resistance of IIMF across the interface between water and MIRK depended on the line velocity and the flow rate ratio. It was likely that the velocity field generated in the slug flow contributed to an increase in the mass transfer of IIMF. 2016 American Institute of Chemical Engineers AIChE J, 62: 2135-2143, 2016