In this study, the potentiality and economic viability of solar photovoltaic (PV) in Ghana was assessed using RETScreen software. 5 MW of grid-connected solar PV power system using SunPower SPR-320E-WHT-D PV module can be harnessed from Navrongo, Bawku, Wa, Tema, Bolgatanga, Axim, Salaga, Kintampo, Kete Krachi, Tamale, Hohoe, Koforidua, Ejura, Takoradi, Bole, Sunyani, Bibiani, Cape coast, Prestea, and Akuse, which requires US$17,752,179 of investment capital and 25,313 m(2) of land for PV installation. The potential of 5 MW grid-connected PV development for Accra, Kumasi, Wenchi, and Tafo are limited. However, there are solar PV energy potentials for low-capacity PV modules for these locations. Investing in solar photovoltaic technology is capital intensive in a developing country like Ghana. However, Government's effort to provide incentives like subsidies and creating the economic environment for private sector investment will boost investment possibilities of renewable energy in Ghana, which can help in curbing the recent power outages and load shedding, thereby increasing productivity and economic resilience.