Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Eun Bi Ku; Kyung Taek Oh; Yu Seok Youn; Eun Seong Lee

Macromolecular Research, Vol.24, No.7, 634-639, July, 2016

DOI10.1007/s13233-016-4090-9 Export Citation

Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Eun Bi Ku, Kyung Taek Oh¹, Yu Seok Youn², and Eun Seong Lee^†

Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi, 14662, Korea
¹College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul, 06974, Korea
²School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, Gyeonggi, 16419, Korea

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In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery.

Keywords:globular poly(ethylene glycol);mitochondria-selective;photodynamic tumor therapy;water-soluble nanoparticle;iodomethyltriphenylphosphonium (IMTP)

[References]

Lee SJ, Koo H, Jeong H, Huh MS, Choi Y, Jeong SY, Byun Y, Choi K, Kim K, Kwon IC, J. Control. Release, 152, 21 (2011)
Jeong H, Huh M, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K, Theranostics, 1, 230 (2011)
Lee PK, Kloser A, J. Drugs Dermatol., 12, 925 (2013)
Renfrew AK, Bryce NS, Hambley T, Chemistry, 21, 15224 (2015)
Li FY, Na K, Biomacromolecules, 12(5), 1724 (2011)
Park SY, Baik HJ, Oh YT, Oh KT, Youn YS, Lee ES, Angew. Chem.-Int. Edit., 50, 1644 (2011)
Oh NM, Kwag DS, Oh KT, Youn YS, Lee ES, Biomaterials, 33, 1884 (2012)
Oh IH, Min HS, Li L, Tran TH, Lee YK, Kwon IC, Choi K, Kim K, Huh KM, Biomaterials, 34, 6454 (2013)
Lee DJ, Youn YS, Lee ES, J. Mater. Chem. B, 3, 4690 (2015)
Park SY, Oh KT, Oh YT, Oh NM, Youn YS, Lee ES, Chem. Commun., 48, 2522 (2012)
Lee UY, Youn YS, Park J, Lee ES, ACS Nano, 8, 12858 (2014)
Lee M, Lee DJ, Youn YS, Lee ES, J. Bioact. Compat. Polym., 31, 167 (2016)
Kim S, Lee DJ, Kwag DS, Lee UY, Youn YS, Lee ES, Carbohydr. Polym., 101, 692 (2014)
Kwag DS, Park K, Oh KT, Lee ES, Chem. Commun., 49, 282 (2013)
Wei Y, Zhou F, Zhang D, Chen Q, Xing D, Nanoscale, 8, 3530 (2016)
Sun JY, Song B, Ye ZQ, Yuan JL, Inorg. Chem., 54(24), 11660 (2015)
Li D, Li L, Li P, Li Y, Chen X, Onco Targets Ther., 8, 703 (2015)
Ling D, Bae BC, Park W, Na K, Biomaterials, 33, 5478 (2012)
Salnikov V, Lukyanenko YO, Frederick CA, Lederer WJ, Lukyanenko V, Biophys. J., 92, 1058 (2007)
Ghasdian N, Buzza DMA, Fletcher PDI, Georgiou TK, Macromol. Rapid Commun., 36(6), 528 (2015)
Mondini S, Drago C, Ferretti AM, Puglisi A, Ponti A, Nanotechnology, 24, 105702 (2013)

[Referenced By]

[1] Lee SJ, Koo H, Jeong H, Huh MS, Choi Y, Jeong SY, Byun Y, Choi K, Kim K, Kwon IC, J. Control. Release, 152, 21 (2011)

[2] Jeong H, Huh M, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K, Theranostics, 1, 230 (2011)

[3] Lee PK, Kloser A, J. Drugs Dermatol., 12, 925 (2013)

[4] Renfrew AK, Bryce NS, Hambley T, Chemistry, 21, 15224 (2015)

[5] Li FY, Na K, Biomacromolecules, 12(5), 1724 (2011)

[6] Park SY, Baik HJ, Oh YT, Oh KT, Youn YS, Lee ES, Angew. Chem.-Int. Edit., 50, 1644 (2011)

[7] Oh NM, Kwag DS, Oh KT, Youn YS, Lee ES, Biomaterials, 33, 1884 (2012)

[8] Oh IH, Min HS, Li L, Tran TH, Lee YK, Kwon IC, Choi K, Kim K, Huh KM, Biomaterials, 34, 6454 (2013)

[9] Lee DJ, Youn YS, Lee ES, J. Mater. Chem. B, 3, 4690 (2015)

[10] Park SY, Oh KT, Oh YT, Oh NM, Youn YS, Lee ES, Chem. Commun., 48, 2522 (2012)

[11] Lee UY, Youn YS, Park J, Lee ES, ACS Nano, 8, 12858 (2014)

[12] Lee M, Lee DJ, Youn YS, Lee ES, J. Bioact. Compat. Polym., 31, 167 (2016)

[13] Kim S, Lee DJ, Kwag DS, Lee UY, Youn YS, Lee ES, Carbohydr. Polym., 101, 692 (2014)

[14] Kwag DS, Park K, Oh KT, Lee ES, Chem. Commun., 49, 282 (2013)

[15] Wei Y, Zhou F, Zhang D, Chen Q, Xing D, Nanoscale, 8, 3530 (2016)

[16] Sun JY, Song B, Ye ZQ, Yuan JL, Inorg. Chem., 54(24), 11660 (2015)

[17] Li D, Li L, Li P, Li Y, Chen X, Onco Targets Ther., 8, 703 (2015)

[18] Ling D, Bae BC, Park W, Na K, Biomaterials, 33, 5478 (2012)

[19] Salnikov V, Lukyanenko YO, Frederick CA, Lederer WJ, Lukyanenko V, Biophys. J., 92, 1058 (2007)

[20] Ghasdian N, Buzza DMA, Fletcher PDI, Georgiou TK, Macromol. Rapid Commun., 36(6), 528 (2015)

[21] Mondini S, Drago C, Ferretti AM, Puglisi A, Ponti A, Nanotechnology, 24, 105702 (2013)