e-harbours is a unique European project that was set out to identify viable energy business cases on the exploitation of energy flexibility, which optimise their operations to match energy demand and supply while taking account of the additional volatility in supply caused by renewable energy sources, improve energy efficiency, and reduce dependence on fossil fuels. In this paper, we propose an integrated multi criteria decision analysis based framework to assess the relative performance of 21 energy business cases, which implemented different demand-side management strategies. Our proposed methodology has the ability to address complex problems involving multiple conflicting interests from various stakeholders, different forms of data, and different fuzzy and crisp relations. We find that business cases based on contract optimisation and offering reserve capacity were ranked relatively high, while those based on trading on the wholesale market or hybrid approaches fared less well. Despite finding viable pilot business cases, e-harbours found that there was little enthusiasm among industrial partners to scale up the pilots. Consequently, EU governments should consider offering attractive incentive programmes for industry engagement in achieving their objectives in reducing greenhouse gas emissions, improving energy supply security, diversifying energy supplies, and improving Europe's industrial competitiveness. (C) 2016 Elsevier Ltd. All rights reserved.