The synthesis of fatty acid methyl ester (FAME) from the high- and low-acid-content feedstock of crude palm oil (CPO) and karanj oil (KO) was conducted over CaO-La2O3-Al2O3 mixed-oxide catalyst. Various reaction parameters were investigated using a batch reactor to identify the best reaction condition that results in the highest FAME yield for each type of oil. The transesterification of CPO resulted in a 97.81% FAME yield with the process conditions of 170 degrees C reaction temperature, 15: 1 DMC-to-CPO molar ratio, 180 min reaction time, and 10 wt.% catalyst loading. The transesterification of KO resulted in a 96.77% FAME yield with the conditions of 150 degrees C reaction temperature, 9: 1 DMC-to-KO molar ratio, 180 min reaction time, and 5 wt.% catalyst loading. The properties of both products met the ASTM D6751 and EN 14214 standard requirements. The above results showed that the CaO-La2O3-Al2O3 mixed-oxide catalyst was suitable for high- and low-acid-content vegetable oil. (C) 2016 Elsevier Ltd. All rights reserved.