Water treatment plants are designed to remove turbidity and apparent colour, and produce safe water from a microbiological and chemical point of view. Disinfection is the step responsible for the microbiological security, for which chlorine is the most widely-used agent, since it can react with organic matter present in raw water to form total trihalomethanes (TTHM), which are harmful to humans. In this context, it is proposed to evaluate the effectiveness of the combined process of coagulation, flocculation, and sedimentation (C/F/S) followed by an activated carbon column. The water for the tests was from the Pirapo River (Brazil) with low colour and turbidity. In C/F/S tests, natural coagulant solutions from Moringa oleifera (MO) degreased with ethanol (MO(et)) and hexane (MO(hex)) were compared to coagulant aluminum polychloride (PAC) with further filtration in an activated carbon column. For all these tests, removal efficiency of apparent colour, turbidity, dissolved organic carbon (DOC), and compounds with UV254nm absorption (UV254nm) were evaluated. The disinfection process was performed and residual chlorine and TTHM formation were evaluated. It was observed that the process of C/F/S using MO(et) followed by filtration through activated carbon was able to reduce the values of physicochemical parameters (96% removal for turbidity and apparent colour, 93% for UV254nm, and 99% for DOC) with reduced formation of TTHM (25.31g/L). Moreover, oil extraction with ethanol presents advantages over hexane due to being a solvent with good operational security, low toxicity, and being a bio-renewable source, all characteristics not present in hexane.