There are many approaches to the issue of agent encapsulation as a method to protect sensitive substances against outer influences. The possibility of the use of inclusion-containing crystals as encapsulation material was investigated. Since many products are water-based media, the low-water-soluble substance salicylic acid (SA) was chosen to investigate its qualities as a container substance. Therefore, the solubility of SA was investigated in dependence on the proportions of the antisolvent water and the solvent ethanol by means of a ternary phase diagram. Moreover, SA container crystals were generated and filled by means of an antisolvent crystallization method. In two case studies, copper sulfate and ascorbic acid could successfully be encapsulated.