The source rock potentiality of Middle Jurassic-Lower Cretaceous source rocks in Meleiha area was investigated through total organic carbon (TOC), Ro%, and pyrolysis analysis for 38 cutting samples collected from six wells. Also, the geochemical burial history profile to estimate the timing of hydrocarbon generation and expulsion of source rocks was constructed. The result revealed that the main hydrocarbon of source rocks, for the Middle Jurassic (Khatatba Fm.), is mainly mature, and has good capability for producing oil till present time. Lower Cretaceous source rocks (Alam El Bueib Fm.) are mature, derived from mixed organic sources, and have fair to good capability to generate gas and oil. Kharita Formations immature source rocks originating from terrestrial origin and have poor to fair potential to produce gas.