In order to study the influence of the cooling fluid parameter on the fluid flow and end part temperature in the end region of the large turbogenerator, a 330-MW water-hydrogenhydrogen cooled turbogenerator is analyzed. The fluid velocity and pressure values from the flow network calculations are applied to the end region as boundary conditions and the losses obtained from 3-D transient electromagnetic field calculations are applied to the end parts as heat sources in the fluid and thermal coupling analysis. After solving the fluid and thermal equations of fluid-solid conjugated heat transfer, the fluid velocity and end part temperature in the turbogenerator end region are gained under the different cooling fluid parameters. The influence of different fluid velocities and fluid temperatures in the water pipe inlet, and in the fan inlet on the fluid flow and end part temperature in the turbogenerator end region is researched. The calculation results of copper shield temperature are compared with the measured values. The calculation results coincident well with the measured values. These provide the important reference for better cooling turbogenerator end region.