The feasibility to reclaim the effluent for reuse in the PVC polymerization step of a PVC factory located in Spain was demonstrated at pilot scale. The treatment of the PVC effluent after the physicochemical step by MBR+RO was carried out during 15 months. Results show a high organics removal and total poly(vinyl alcohol) abatement after one month of reclamation. Thus, the current bottleneck associated with the implementation of this technology in the presence of poly(vinyl alcohol) was removed. Full nitrification and nitrogen removal efficiencies close to 80% were achieved working under anoxic/aerobic conditions. Moreover, under appropriate working conditions the system showed high robustness in front of different events/instabilities and inlet characteristics/intermittent load due to quickly recovered stability and production of a high-quality permeate for demineralization in the desalination unit. In addition, the permeability in the ultrafiltration stage showed high stability and could be very well recovered after chemical cleanings. The two-pass RO permeate quality fit the required specifications for being reused in the PVC process (conductivity <10 its cm(-1)) working under both full aerobic and anoxic/aerobic conditions during biological treatment. Moreover, high-quality PVC resins were obtained when the recycled effluent was used as fresh water in the polymerization step, thus demonstrating the feasibility of further closing the water loop within the PVC industry.