NH3 was used as acid absorbent to intensify the reactions between aniline and benzoyl chloride in a microstructured chemical system in this work. By suppressing the side reaction, the addition of NH3 could reduce the reaction time needed for 99% reactants conversation to less than 1/10 of the condition without NH3. Furthermore, a complete kinetic model containing two rapid main reactions and two reversible consecutive side reactions was established, and six reaction rate constants and their corresponding activation energies and pre-exponential factors as well as confidence intervals were determined precisely. The accuracy of the obtained parameters was verified by comparing the calculated data with experimental data at extensional temperature. The kinetic model was used to optimize the intensification operating conditions, and effects of reactants concentration, temperature, NH3 addition amount, and NH3 feed methods were,discussed based,on the simulation results. This work proves that the microstructured chemical system not only provides an effective intensification ability but also develops a reliable platform for kinetic studies.