Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin

Na Ri Im; Kyoung Mi Kim; Suh Ji Young; Soo Nam Park

Korean Journal of Chemical Engineering, Vol.33, No.9, 2738-2746, September, 2016

DOI10.1007/s11814-016-0146-y Export Citation

Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin

Na Ri Im, Kyoung Mi Kim, Suh Ji Young, and Soo Nam Park^†

Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea

E-mail:

We developed a drug-in-cyclodextrin-in-elastic liposomes (DCEL) system to enhance transdermal delivery of caffeic acid (CA). Hydroxypropyl-β-cyclodextrin (HP-β-CD) was used as a hydrophilic CD. Elastic liposomes (EL) contained polyethylene glycol-free Tego® care 450 as an edge activator. Properties of the CA-HP-β-CD inclusion complex loaded in EL (CD-EL) as DCEL system were compared to characteristics of conventional liposomes (CL), EL, and CD-CL. Particle size, deformability, entrapment efficiency (EE%), stability, and vesicle morphology were characterized in liposome preparations. In addition, in vitro release and skin permeation were analyzed. We found that including Tego® care 450 reduced vesicle size and increased membrane deformability. The addition of HP-β-CD enhanced CA EE% of liposomes almost 1.6-fold that of liposomes without HP-β-CD. Moreover, CD-EL complex showed better controlled release profiles and higher skin permeability than CL and EL. We propose that the DCEL system can be a promising drug delivery vehicle for transdermal delivery of CA.

Keywords:Caffeic Acid;Hydroxypropyl-β-cyclodextrin;Elastic Liposome;Drug-in-cyclodextrin-in-elastic Liposome;Skin Permeation

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[Referenced By]

[1] Honeywell-Nguyen PL, Bouwstra JA, Drug Discovery Today Technol., 2, 67 (2005)

[2] Otto DP, Villiers MM, Ther. Deliv., 5, 961 (2014)

[3] Park SN, Lee MH, Kim SJ, Yu ER, Biochem. Biophys. Res. Commun., 435(3), 361 (2013)

[4] Choi MJ, Maibach HI, Int. J. Cosmet. Sci., 27, 211 (2005)

[5] Cevc G, Blume G, BBA-Biomembranes, 1104, 226 (1992)

[6] Elsayed MA, Abdallah Y, Naggar F, Khalafallah M, Int. J. Pharm., 332, 1 (2007)

[7] Johnson W, Int. J. Toxicol., 20, 13 (2001)

[8] Han SB, Kwon SS, Jeong YM, Kong BJ, Yu ER, Park SN, Polym. Korea, 38(6), 694 (2014)

[9] Park SN, Lim MS, Park MA, Kwon SS, Han SB, Polym. Korea, 36(6), 705 (2012)

[10] Maestrlli F, Gonzalez-Rodriguez ML, Rabasco AM, Ghelardini C, Mura P, Int. J. Pharm., 395, 222 (2010)

[11] Im NR, Kim HS, Lim JW, Kim KJ, Noh GY, Park SN, Appl. Chem. Eng., 26(5), 563 (2015)

[12] Zhang W, Wang G, Falconer JR, Baguley BC, Shaw JP, Liu J, Xu H, See E, Sun J, Aa J, Wu Z, Pharm. Res., 32, 1451 (2015)

[13] McCormack B, Gregoriadis G, Int. J. Pharm., 112, 249 (1994)

[14] Chen J, Lu WL, Gu W, Lu SS, Chen ZP, Cai BC, Yang XX, Expert. Opin Drug. Deliv., 11, 565 (2014)

[15] Chen J, Lu WL, Gu W, Lu SS, Chen ZP, Cai BC, Expert. Opin Drug. Deliv., 10, 845 (2013)

[16] Cal K, Centkowska K, Eur. J. Pharm. Biopharm., 68, 467 (2008)

[17] Kaur N, Puri R, Jain SK, Aaps PharmSciTech, 11, 528 (2010)

[18] Loftsson T, Brewster ME, J. Pharm. Pharmacol., 63, 1119 (2011)

[19] Kang NJ, Lee KW, Shin BJ, Jung SK, Hwang MK, Bode AM, Heo YS, Lee HJ, Dong Z, Carcinogenesis, 30, 321 (2009)

[20] Gupta A, Maheshwari DK, Khandelwal G, J. Appl. Nat. Sci., 5, 459 (2013)

[21] Astorino TA, Alkadhi KA, in Caffeine: chemistry, analysis, function and effects, Preedy VR, Eds., Royal Society of Chemistry (2012).

[22] Kim BY, Jeong JS, Kwon HJ, Lee JH, Hong SP, Kor. J. Herbol., 23, 67 (2008)

[23] Fathi M, Mirlohi M, Varshosaz J, Madani G, J. Nanomater., 2013, 9 (2013)

[24] Zhang M, Li J, Zhang L, Chao J, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 71, 1891 (2009)

[25] Mohan PRK, Sreelakshmi G, Muraleedharan CV, Joseph R, Vib. Spectrosc., 62, 77 (2012)

[26] van den Bergh BAI, Wertz PW, Junginger HE, Bouwstra JA, Int. J. Pharm., 217, 13 (2001)

[27] Shaji J, Iyer S, Asian J. Pharm., 6, 218 (2012)

[28] Delrivo A, Zoppi A, Longhi MR, Carbohydr. Polym., 87, 1980 (2012)

[29] Liu B, Zhao J, Liu Y, Zhu X, Zeng J, J. Agric. Food Chem., 60, 12501 (2012)

[30] Gillet A, Lecomte F, Hubert P, Ducat E, Evrard B, Piel G, Eur. J. Pharm. Biopharm., 79, 43 (2011)

[31] Alomrani AH, Shazly GA, Amara AA, Badran MM, Colloids Surf. B: Biointerfaces, 121, 74 (2014)

[32] Guo F, Wang J, Ma M, Tan F, Li N, J. Mater. Sci. -Mater. Med., 26, 1 (2015)

[33] Hommoss A, PhD Thesis, Berlin, Free University of Berlin (2009).

[34] Aggarwal N, Goindi S, Int. J. Pharm., 437, 277 (2012)

[35] El Maghraby GMM, Williams AC, Barry BW, Int. J. Pharm., 276, 143 (2004)

[36] Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, He J, Alb A, John V, Pochampally R, Nanomedicine, 8, 440 (2012)

[37] Agashe H, Lagisetty P, Sahoo K, Bourne D, Grady B, Awasthi V, J. Nanopart. Res., 13, 2609 (2011)

[38] Shaji J, Lal M, Int. J. Curr. Pharm. Res., 6, 16 (2014)

[39] Nava G, Pinon E, Mendoza L, Mendoza N, Quintanar D, Ganem A, Pharmaceutics, 3, 954 (2011)

[40] Hussain A, Samad A, Ramzan M, Ahsan MN, Rehman ZU, Ahmad FJ, Drug. Deliv., 14, 1 (2014)

[41] Singh HP, Tiwary AK, Jain S, Yakugaku Zasshi, 130, 397 (2010)

[42] Lira MC, Ferraz MS, da Silva DG, Cortes ME, Teixeira KI, Caetano NP, Santos-Magalhaes NS, J. Incl. Phenom. Macrocycl. Chem., 64, 215 (2009)

[43] Masson M, Loftsson T, Masson G, Stefansson E, J. Control. Release, 59, 107 (1999)

[44] Nagarsenker MS, Amin L, Date AA, AAPS PharmSciTech, 9, 1165 (2008)

[45] Chirio D, Cavalli R, Trotta F, Carlotti ME, Trotta M, J. Incl. Phenom. Macrocycl. Chem., 57, 645 (2007)