The therapeutic potential of quercetin is mostly hampered by its low water solubility and poor absorption The aim of this study was to enhance the dissolution rate of quercetin by molecular encapsulation with cyclodextrin nanosponges. The inclusion complexes were obtained by freeze-drying method. Inclusion complexes were characterized by Fourier Transformed Infrared Spectroscopy (FTIR), x-ray diffractionR (X D), Differential Scanning Calorirnetni (DSC), transmission electron microscopy (TEM), and dissolution testing. FTIR, XRD, and DSC studies confirmed the interactions of quercetin with nanosponges. TEM images revealed the spherical morphology of complexes. The dissolution of the drug nanosponge complex was significantly higher compared with the pure drug in simulated intestinal fluid (SIF; pH 6.8). The results indicated that the degree of cross-linking has the significant influence on dissolution. Nanosponges with lower degree of cross-linking released 91% of the drug within 45 min, whereas nanosponges with higher degree of cross-linking resulted in sustained release up to 24 h.