Fluid flow maldistribution is considered as one of the main causes of performance deterioration in various energy and process systems, especially when parallel micro- or mini-channel fluidic networks are involved. For a specific purpose, the optimal flow distribution is not necessarily uniform. However, specific non-uniform distributions are somewhat more difficult to achieve than uniform ones. The insertion of a geometrically optimized baffle has been numerically confirmed as an effective solution to this issue, but experimental validation is still lacking which is indispensable for bridging the gap between theory and practice. This paper presents a numerical and experimental investigation on the realization of target flow distribution among parallel mini-channels, using the optimized baffle insertion method. A 15-channel fluidic network integrated with the distributor and the collector is fabricated and tested. Various perforated baffles are optimized and fabricated corresponding to different target distributions (uniform, ascending and descending). PIV technique is used for the flow distribution measurement while CFD simulations are also performed for comparison. CFD results and PIV data show that different target distributions could be successfully achieved by the optimized baffle insertion method. The robustness of the optimized baffle for uniform distribution is also evaluated and discussed to provide some guidelines for future applications. (C) 2016 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.