Hydrogen peroxide (H2O2) is closely related to people's life in a lot of respects, including food, health, and environment and so on. High performance detection of H2O2 is of importance in chemical and biological fields. In this study, we synthesized reduced graphene oxide-supported tin oxide nanoclusters (SnO2-rGO) as electrochemical sensing material for H2O2 detection. From scanning electron microscopy (SEM) and high resolution transmission electron microscopy (HRTEM) images, uniform SnO2 nanoclusters with a diameter of 3-5 nm are evenly dispersed on the surface of rGO. Electrochemical studies showed that the sensing platform fabricated from SnO2-rGO possesses fast mass transport, good electrical conductivity and high sensitivity and selectivity for the detection of H2O2. The SnO2-rGO composite exhibited a linear current response to H2O2 from 0.5 to 800 mu M with a fast response within 2 s. The detection limit was calculated to be 0.478 mu M. The present study shows that tiny SnO2 clusters supported on rGO can be applied as a promising type of sensing material for electrochemical detection of H2O2. (C) 2016 Elsevier Ltd. All rights reserved.