This work presents an energy and economic analysis to assess the profitability of energy rehabilitation operations in the envelope of a block of residential dwellings in Southern Spain. The work rates the influence that a set of hypotheses of interventions in the opaque part of the envelope exerts on annual energy demand (better insulation of the facade, interior partitions, roof and ground floors) in addition to its semi-transparent part (improvements in the airtightness of the building openings, the glass windows, devices of control of solar radiation and their possible combinations or settings of energy rehabilitation). These models have been designed for the context of a Mediterranean climate, and the simulation tool, Design Builder-Energy Plus has been selected to generate the computing models and establish their energy demands. This work concludes that the most profitable setting is that which combines: a facade restored by inner cladding with insulation superior to the regulatory limit, roof and ground isolation provided by the inner facing, double-glazed windows with low emissivity and aluminium frames with a break in the thermal bridge, protection from mobile device shading, and an efficient use of the terraces as solar collectors. (C) 2016 Elsevier B.V. All rights reserved.