We demonstrate that the conformation, packing mode, and blue fluorescence of a soft piezo-fluorochromic compound can be preserved by structurally fixing it into a solid calcium metal-organic framework (Ca-MOF, LIFM-40), which can survive pressures up to 8 MPa. DFT calculations have been combined with experimental results to inditate that the ligands adopting a specific conformation and packing without pi...pi interactions are the reasons for its rigidified blue emission.