In the present work, temperature dependence of heat capacity of methylprednisolone aceponate has been measured for the first time over the range from 7 K to 346 K by precision adiabatic vacuum calorimetry. Based on the experimental results, the thermodynamic functions of the methylprednisolone aceponate, namely, the heat capacity, enthalpy H degrees(T)-H degrees(0), entropy S degrees(T)-S degrees(0) and Gibbs function G degrees(T)-H degrees(0) have been determined for the range from T/K -> 0-333. The enthalpy of combustion (-14304.4 +/- 9.1) kJ . mol (1) of the methylprednisolone aceponate was determined for the first time using high-precision combustion calorimeter. The standard molar enthalpy of formation in the crystalline state (-1465.3 +/- 9.8) kJ . mol (1) of compound at 298.15 K was derived from the combustion experiments. Using a combination of the adiabatic and combustion calorimetry results the thermodynamic functions of formation of the folic acid dihydrate at T = 298.15 K and p = 0.1 MPa have been calculated. (C) 2016 Elsevier Ltd.