Spiropyran-containing polymer nanoparticles have found interesting applications in various fields. Here, redispersible multi-responsive latex nanoparticles have been prepared by using RAFT-mediated polymerization. Poly (dimethylamino ethyl methacrylate (DMAEMA)-b-methyl methacrylate (MMA)) was used as a pH-responsive reactive macro-RAFT surfactant (MRS) with molecular weight of 3390 g mol(-1). Afterwards, a series of photo-responsive latex nanoparticles of poly (MMA-co-spiropyranethylacrylate (SPEA))were prepared through emulsion polymerization in the presence of various amounts of MRS. Then the obtained nanoparticles were characterized. Nanoparticles of about 100 nm with narrow size distribution were obtained with photochromic response in the absorption wavelength of 500-650 nm. The prepared MRS could function as an actuator for repeatable dispersion/aggregation of the PMMA-based photo-responsive latex nanoparticles. The stimuli-responsive characteristics were investigated by multiple triggers including pH, CO2/N-2 and UV-Vis irradiation. The obtained latex responds to above triggers quickly by visual changes in color (acidochromism/basochromism) and dispersibility with reasonable reproducibility. (C) 2016 Elsevier Ltd. All rights reserved.