This paper describes how two different chip-based liquid sensors have been used for experimental Fast DSC measurements on human serum. The paper starts with describing the first chip-based liquid sensor, based on the XI-400 chip. Repeatability (measurements with the same chip) and reproducibility (measurements with different chips) measurements are described when a linear or a second-degree polynomial baseline is subtracted from the raw data. Human serum with deviating Immunoglobulin levels was measured. The second half of the paper describes the second generation chip based-liquid sensor, based on the XI-468B chip. The new more sensitive chip is described and used for measurements with ten serum samples from healthy individuals and five serum samples from patients diagnosed with CCRCC kidney cancer. Differences are found between the serum from healthy individuals and the serum from the CCRCC kidney cancer patients. (C) 2016 Elsevier B.V. All rights reserved.