We have measured the alignment influence on ion yields of CH3I and CH3Br molecules in the laser intensity regime from 10(13) W/cm(2) to 10(15) W/cm(2). The hexapole state-selection technique combined with laser induced alignment has been employed to obtain aligned (< P-2 (cos theta)> = 0.7) and anti-aligned (< P-2(cos theta)> = -0.1) CH3I and CH3Br molecules. The ratio of saturation intensities observed for the CH3I and CH3Br molecules with different alignments are simulated using a modified PPT model for molecules considering different orbitals and a good agreement has been achieved, indicating the contribution from multiple orbitals in the ionization. (C) 2016 Elsevier B.V. All rights reserved.